Kinetics And Stability Studies Of Formulated Micro/Nano Suspension Of Metronidazole
Kinetics And Stability Studies Of Formulated Micro/Nano Suspension Of Metronidazole
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Abstract
Kinetic models describe the overall release of drugs from dosage form because qualitative and quantitative
changes do occur in a formulation. These changes may alter drug release and in vivo performance hence the
application of methods that facilitates product development and thereby reducing the necessity of bio studies,
this leads to the adoption of in vitro drug dissolution analysis that involves the use of dialysis membrane and
adopting a diffusion method. Stability studies revealed that the formulated nano/micro suspension was more
stable at refrigerated condition (4OC) showing no significant change in particle size distribution, %EE and
release characteristics after 3months of study. The in vitro drug release analysis shows drug release from the
various formulations (S, Y and W) to follow zero order release kinetics and this was confirmed after
determination of line of best fit and from the correlation coefficients values obtained following the
consideration of various kinetic models such as: first order, zero order, Korsmeyer- Peppas and Higuchi
models. The stability studies and shelf life determinations of the formulations show formulation S, having a shelf
life of 4.598 months, while that of formulation Y and W, are 4.808 months and 3.085 months respectively.
These values could be related to the size of the particles formed using the various polymers which might
influence their film forming and protective ability over the particles. The protective ability of tragacanth when
used alone seem not to be sustained over a long period of time and this reduced stability effect could lead to
short shelf life as a result of the tendency of Ostwald ripening and agglomeration of particles after a short
period of storage but when compared to the formulation involving C.olitorious gum used alone or that
consisting of C.olitorious and Tragacanth, stability was sustained signifying better protective ability of the
polymer.
Article Details
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